Efficacy of N acetylcysteine vs metformin on biochemical and clinical parameters in women with polycystic ovarian syndrome in a tertiary care hospital

: Ovarian dysfunction syndrome, or PCOS, is characterised by hyperandrogenism, enlarged cystic ovaries, and persistent anovulation in women of reproductive age. These coexist with insulin resistance, dyslipidemia, obesity. To enhance menstruation pattern, sensitivity, treat a metformin replacement that has few side effects required. study the N acetyl cysteine PCOS compare commonly used Metformin. evaluate if can substitute Metformin treatment clinical parameters like BMI, menstrual pattern biochemical FBS lipid profile. A prospective randomized control was conducted Obstetrics Gynaecology department Shri Sathya Sai medical college. 60 (diagnosed Rotterdam criteria) age group 18 to 45 were included this study. Subjects randomly assigned into 2 groups. Group M received 500mg TDS acetylcysteine 600mg TDS. Clinical contributing metabolic syndrome such as Fasting blood sugars profile noted before after completion along drugs. 30 NAC completed statistically significant decrease Waist hip ratio both The mean difference post (3.63 vs 4.16) BMI (0.014 0.017) waist ratio. Both treatments led improvement showed better results compared M. efficient improving parameters. However, WHR, FBS, more metformin.